Don't think it has happened before tbh. I feel like it's something along the likes of using zoan awakening too much increases the chance you turn into an animal of pure instinct. How it interacts with devil fruits that are based on mythological beings/'gods'. Will remain to be seen.
Also...
I do remember Kaido talking about being careful with awakening there's a risk the user can lose themselves in their awakened zoan form. So I hope this won't cause issues for Luffy in the future.
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